Computational modeling of the MAPK pathway using NetLogo
DOI:
https://doi.org/10.69681/lajae.v1i1.3Keywords:
Computational modeling, MAPK pathway, NetLogo, SystemsbiologyAbstract
The signal transduction pathways have an important role in cell growth, as they are the primary means of communication of cells with their environment, which determines the activity of cells promoting responses such as proliferation, differentiation, migration, development, apoptosis, etc., there have been models representing these pathways using different techniques, such as ODEs, stochastic methods, Petri nets, pi calculation, Boolean networks, Bayesian networks, cellular automaton and agent-based systems, among others. In this research, an agent-based modeling and simulation of subsequent events after activation of the Ras molecule in the intracellular MAPK pathway section is presented, using a multi-agent programmable modeling environment called NetLogo.
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